Crams rule free download as powerpoint presentation. An atom usually carbon with 4 different substituents is called a stereogenic center or stereocenter. Crams rule in stereochemistryasymmetric synthesiscrams. R and s configuration using cahn ingold prelog priority rules. Crams chelation modelcrams chelate rule crams chelation anticrams rule in stereochemistry duration. Stereoisomers are molecules whose atomic connectivity is the same but whose three dimensional arrangement of atoms in space is different. Crams rule in stereochemistryasymmetric synthesiscrams rule pdf. In general it is most clear if all rings of an orthofused ring system or saturated derivatives are kept in. Enantiomer, configuration, racemic, diastereisomer, purification. Two compounds that are nonsuperimposable mirror images the two hands are called enantiomers. The rule of steric control of asymmetric induction in the syntheses of acyclic systems donald j. Crams rule, csir net organic chemistry problem by dr.
Stereochemistry of organic compounds eliel pdf free download. Module 8 stereochemistry lecture 20 stereochemistry i nptel. Consider two of the compounds we produced while finding all the isomers of c. Stereochemistry an introduction pdf 40p advertisement this note covers the following topics. These rules give the absolute configuration, r and s for each chiral center within a compound. Strict rules for drawing stereochemistry are not possible. This has sweeping implications in biological systems. R and s configurations for chiral molecules using cahningoldprelog priority rules for ranking substituents by this. Stereochemistry of tetrahedral carbons, stereoisomers stereoisomers, stereocenter, chiral, enantiomers, racemic mixture, configuration of stereocenters, molecules with multiple stereocenters, tartaric acid and enantiomers. It generally relates to grignard addition to chiral pyruvates made using chiral alcohols fig 1.